Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340169 | 1.00 | RET (0.49) | RETHIF1AKMT2AMEN1MAPT | |
| SCHEMBL6329674 | 0.91 | RET (0.48) | RETKMT2AMEN1MAPTHDAC1 | |
| SCHEMBL6329682 | 0.91 | RET (0.48) | RETKMT2AMEN1MAPTHDAC1 | |
| SCHEMBL6333335 | 0.91 | RET (0.54) | RETALDH1A1 | |
| SCHEMBL6333341 | 0.91 | RET (0.54) | RETALDH1A1 | |
| SCHEMBL6336574 | 0.88 | RET (0.43) | RETKMT2AMEN1RAB9A | |
| SCHEMBL6336573 | 0.88 | RET (0.43) | RETKMT2AMEN1RAB9A | |
| SCHEMBL6338483 | 0.87 | RET (0.42) | RETKMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL6338488 | 0.87 | RET (0.42) | RETKMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL6340159 | 0.86 | ACHE (0.48) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |