Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.82 |
| ▸ | FPR3 | P25089 | 2/20 | 0.82 |
| ▸ | TSPO | P30536 | 2/20 | 0.82 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362035 | 0.90 | CRHR1 (0.80) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6779312 | 0.90 | CRHR1 (0.80) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Cp-154526 SCHEMBL5707848 | 0.90 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Cp-154526 SCHEMBL31012286 | 0.89 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| Cp-154526 SCHEMBL7165019 | 0.89 | CRHR1 (1.00) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL8359748 | 0.89 | CRHR1 (0.77) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6785014 | 0.87 | CRHR1 (0.77) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6773970 | 0.85 | CRHR1 (0.79) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6774652 | 0.85 | CRHR1 (0.78) | CRHR1FPR3TSPOTMEM97TDP1 | |
| [18F]Fbppa SCHEMBL31438306 | 0.85 | CRHR1 (0.82) | CRHR1FPR3TSPOTMEM97TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765008-B1 | PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES; ANXIOLYTIC AGENTS; NERVOUS SYSTEM, BRAIN, PSYCHOLOGICAL, EATING, AND GASTROINTESTINAL DISORDERS; CORTICOTROPIN-RELEASING FACTOR ANTAGONISTS | PFIZER INC | 2004-07-20 | — | — | US | disclosed |
| EP-0674641-B1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| WO-1994013676-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |