Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.57 |
| ▸ | CCND1 | P24385 | 8/20 | 0.57 |
| ▸ | CRHR1 | P34998 | 7/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215862 | 0.83 | CDK4 (0.44) | CDK4CCND1CRHR1PARP1CCNE2 | |
| SCHEMBL3615202 | 0.81 | CDK4 (0.42) | CDK4CCND1CRHR1PARP1CCNE2 | |
| SCHEMBL6214653 | 0.81 | CDK4 (0.42) | CDK4CCND1PARP1CCNE2CCNE1 | |
| SCHEMBL6780750 | 0.78 | CDK4 (0.52) | CDK4CCND1CRHR1PARP1CCNE2 | |
| SCHEMBL6219382 | 0.77 | CDK4 (0.40) | CDK4CCND1CRHR1CCNE2CCNE1 | |
| SCHEMBL6217206 | 0.76 | CDK4 (0.49) | CDK4CCND1PARP1CCNE2CCNE1 | |
| SCHEMBL6216752 | 0.76 | CDK4 (0.49) | CDK4CCND1CRHR1CCNE2CCNE1 | |
| SCHEMBL6216606 | 0.76 | CDK4 (0.39) | CDK4CCND1PARP1CCNE2CCNE1 | |
| SCHEMBL6850270 | 0.75 | PARP1 (0.53) | CDK4CCND1CRHR1PARP1CCNE2 | |
| SCHEMBL6784008 | 0.75 | CDK4 (0.55) | CDK4CCND1CRHR1PARP1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765008-B1 | PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES; ANXIOLYTIC AGENTS; NERVOUS SYSTEM, BRAIN, PSYCHOLOGICAL, EATING, AND GASTROINTESTINAL DISORDERS; CORTICOTROPIN-RELEASING FACTOR ANTAGONISTS | PFIZER INC | 2004-07-20 | — | — | US | disclosed |
| EP-0674641-B1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| WO-1994013676-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |