Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.55 |
| ▸ | CCND1 | P24385 | 12/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | FPR3 | P25089 | 2/20 | 0.43 |
| ▸ | TSPO | P30536 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218669 | 0.82 | CDK4 (0.42) | CDK4CCND1PARP1CCNE2CCNE1 | |
| SCHEMBL6217714 | 0.82 | CDK4 (0.41) | CDK4CCND1PARP1CCNE2CCNE1 | |
| SCHEMBL6218693 | 0.77 | CDK4 (0.46) | CDK4CCND1PARP1CCNE2CCNE1 | |
| SCHEMBL6213926 | 0.77 | CDK4 (0.47) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL4562079 | 0.77 | CA12 (0.49) | CDK4CCND1PARP1CCNE1CDK2 | |
| SCHEMBL6780074 | 0.75 | CDK4 (0.57) | CDK4CCND1PARP1CRHR1CCNE2 | |
| SCHEMBL6218319 | 0.75 | CDK4 (0.36) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6213942 | 0.75 | CDK4 (0.43) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6216498 | 0.74 | PDE2A (0.39) | CDK4CCND1CRHR1CA12CA1 | |
| SCHEMBL6216009 | 0.72 | CDK4 (0.36) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765008-B1 | PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES; ANXIOLYTIC AGENTS; NERVOUS SYSTEM, BRAIN, PSYCHOLOGICAL, EATING, AND GASTROINTESTINAL DISORDERS; CORTICOTROPIN-RELEASING FACTOR ANTAGONISTS | PFIZER INC | 2004-07-20 | — | — | US | disclosed |
| EP-0674641-B1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| WO-1994013676-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |