Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778530 | 0.90 | PARP1 (0.52) | PBKPARP1PARP2 | |
| SCHEMBL5074338 | 0.90 | PARP1 (0.52) | PBKPARP1PARP2 | |
| SCHEMBL6783310 | 0.86 | PBK (0.52) | PBKPARP1POLBPARP2GID4 | |
| SCHEMBL5620715 | 0.85 | PARP1 (0.53) | PBKKDM5AKDM5BPARP1POLB | |
| SCHEMBL6786430 | 0.80 | PARP1 (0.50) | PARP1HTR2BPARP2 | |
| SCHEMBL6783911 | 0.80 | PARP1 (0.50) | PARP1HTR2BPARP2 | |
| SCHEMBL6786783 | 0.80 | PARP1 (0.50) | PARP1HTR2BPARP2 | |
| SCHEMBL6780399 | 0.79 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL6782750 | 0.79 | PARP1 (0.52) | PARP1PARP2 | |
| SCHEMBL5072053 | 0.78 | PARP1 (0.54) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737421-B1 | 4-CARBOXYAMIDO SUBSTITUTED; NEURODEGENERATIVE DISEASES; NEURONAL DAMAGE | ABBOTT GMBH & CO. KG (DE) | 2004-05-18 | — | — | US | disclosed |