⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542845 | 0.78 | — | — | |
| SCHEMBL3861835 | 0.77 | — | — | |
| SCHEMBL25315484 | 0.76 | — | — | |
| SCHEMBL3390030 | 0.68 | — | — | |
| SCHEMBL2537740 | 0.68 | — | — | |
| SCHEMBL12613763 | 0.67 | — | — | |
| SCHEMBL16133517 | 0.66 | — | — | |
| SCHEMBL9060396 | 0.65 | — | — | |
| SCHEMBL669424 | 0.65 | — | — | |
| SCHEMBL17033028 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199609-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2024-06-20 | — | — | US | disclosed |
| US-11905283-B2 | Compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2024-02-20 | — | — | US | disclosed |
| US-20210300919-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2021-09-30 | — | — | US | disclosed |
| CN-113365999-A | Capsid protein assembly inhibitors containing pyrroloheterocycles | 正大天晴药业集团股份有限公司 | 2021-09-07 | — | — | CN | disclosed |
| US-10934285-B2 | Compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2021-03-02 | — | — | US | disclosed |
| CN-109790168-A | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | 吉利德科学公司 | 2019-05-21 | — | — | CN | disclosed |
| EP-2760829-A1 | PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013048982-A1 | PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |
| US-6727275-B2 | ANTIINFLAMMATORY, ANTIALLERGEN, AND ANTIASTHMATIC AGENTS | UCB, S.A./N.V. (BE) | 2004-04-27 | — | — | US | disclosed |