⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372744 | 0.80 | — | — | |
| SCHEMBL9496924 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL25308672 | 0.78 | EGLN1 (0.43) | — | |
| SCHEMBL15577373 | 0.77 | — | — | |
| SCHEMBL27584672 | 0.74 | CHRNB2 (0.40) | — | |
| SCHEMBL2536727 | 0.70 | — | — | |
| SCHEMBL6780565 | 0.68 | — | — | |
| SCHEMBL8693124 | 0.65 | — | — | |
| SCHEMBL2537740 | 0.65 | — | — | |
| SCHEMBL13472088 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102762576-B | Benzoxazepine PI3K inhibitor compounds and methods of use | HOFFMANN LA ROCHE | 2015-04-22 | — | — | CN | claimed |
| EP-0083378-A1 | Tetrahydronicotinamide derivatives, a process for producing the same and a pharmaceutical composition comprising the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-07-13 | — | — | EP | claimed |
| US-4361572-A | Tetrahydronicotinamide derivative, pharmaceutical compositions and use | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-11-30 | — | — | US | claimed |
| US-8980907-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-8889635-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140128327-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-08 | — | — | US | disclosed |
| US-20100160299-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-06-24 | — | — | US | disclosed |
| WO-2010039861-A2 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-04-08 | — | — | WO | disclosed |
| CN-101578100-A | Use of neuroprotective compounds for obtaining drugs for treating neurodegenerative diseases | SERVIER LAB (FR) | 2009-11-11 | — | — | CN | disclosed |
| CN-101257905-A | Novel 1h-indole-pyridinecarboxamide derivatives and 1h-indole-piperidinecarboxamide and their use as hydroxalase tyrosine inducers | SERVIER LAB (FR) | 2008-09-03 | — | — | CN | disclosed |
| US-6894168-B2 | Carbamoyl tetrahydropyridine derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-05-17 | — | — | US | disclosed |
| EP-0083378-A1 | Tetrahydronicotinamide derivatives, a process for producing the same and a pharmaceutical composition comprising the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-07-13 | — | — | EP | disclosed |
| US-4361572-A | Tetrahydronicotinamide derivative, pharmaceutical compositions and use | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-11-30 | — | — | US | disclosed |