Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273235 | 1.00 | LMNA (0.71) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6276242 | 1.00 | LMNA (0.71) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6273825 | 1.00 | LMNA (0.71) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6275012 | 1.00 | LMNA (0.71) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6268668 | 1.00 | LMNA (0.71) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6268678 | 0.99 | LMNA (0.72) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6270942 | 0.97 | LMNA (0.75) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6274968 | 0.94 | LMNA (0.78) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6269160 | 0.92 | SOAT1 (0.71) | LMNASMN1; SMN2SOAT1POLBNPC1 | |
| SCHEMBL6214846 | 0.88 | LMNA (0.55) | LMNASMN1; SMN2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825223-B2 | ACYL COENZYME A CHOLESTEROL ACYLTRANSFERASE (ACAT) INHIBITORS; 2-SUBSTITUTED BENZIMIDAZOLE, BENZOXAZOLE, AND BENZOTHIAZOLES | KOWA COMPANY, LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-6204278-B1 | Anilide compounds, including use thereof in ACAT inhibitition | KOWA COMPANY, LTD. (JP) | 2001-03-20 | — | — | US | disclosed |
| EP-0807627-A2 | Anilide compounds as ACAT inhibitors | Kowa Company Ltd. (JP) | 1997-11-19 | — | — | EP | disclosed |