Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.47 |
| ▸ | HRAS | P01112 | 13/20 | 0.46 |
| ▸ | ESR1 | P03372 | 13/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776711 | 1.00 | HDAC1 (0.49) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL6785507 | 0.96 | HDAC1 (0.46) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL6775707 | 0.94 | HDAC1 (0.44) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL6785845 | 0.91 | HDAC1 (0.49) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL6777138 | 0.91 | HDAC1 (0.51) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL6782496 | 0.91 | HDAC1 (0.51) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL7116979 | 0.90 | HRAS (0.53) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL7123705 | 0.90 | HRAS (0.53) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL7504035 | 0.89 | HRAS (0.60) | HDAC1HDAC2HDAC8TOP1HRAS | |
| SCHEMBL3678651 | 0.89 | HRAS (0.60) | HDAC1HDAC2HDAC8TOP1HRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753316-B1 | 3-ACRYLAMIDOPYRAZOLE-5-CARBOXAMIDE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-06-22 | — | — | US | disclosed |