Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.51 |
| ▸ | MMP13 | P45452 | 12/20 | 0.51 |
| ▸ | MMP9 | P14780 | 11/20 | 0.51 |
| ▸ | MMP1 | P03956 | 10/20 | 0.51 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206158 | 0.90 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6657885 | 0.88 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6656775 | 0.88 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6656626 | 0.87 | ADAM17 (0.52) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3944724 | 0.87 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3944727 | 0.87 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6661478 | 0.87 | ADAM17 (0.63) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3949997 | 0.84 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL3942782 | 0.81 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1ADAM10 | |
| SCHEMBL6661539 | 0.81 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |