Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.60 |
| ▸ | ITGAV | P06756 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834692 | 0.92 | ITGB3 (0.54) | ITGB3ITGAVHSD17B10ITGA2BMEN1 | |
| SCHEMBL6778762 | 0.90 | ITGB3 (0.51) | ITGB3ITGAVGSK3BHSD17B10MEN1 | |
| SCHEMBL6778398 | 0.87 | ITGB3 (0.59) | ITGB3ITGAVMEN1KMT2ALMNA | |
| SCHEMBL7835493 | 0.86 | ITGB3 (0.53) | ITGB3ITGAVGSK3BLMNAMAPK1 | |
| SCHEMBL6777052 | 0.86 | ITGB3 (0.59) | ITGB3ITGAVHSD17B10ITGA2BMEN1 | |
| SCHEMBL7377590 | 0.84 | GSK3B (0.58) | ITGB3ITGAVGSK3BHSD17B10MEN1 | |
| SCHEMBL6773510 | 0.84 | ITGB3 (0.54) | ITGB3ITGAVMEN1KMT2ARAB9A | |
| SCHEMBL6778847 | 0.83 | ITGB3 (0.53) | ITGB3ITGAVMEN1KMT2A | |
| SCHEMBL27484811 | 0.82 | ITGB3 (0.52) | ITGB3ITGAVHSD17B10ITGA2BMEN1 | |
| SCHEMBL240965 | 0.81 | ITGB3 (0.59) | ITGB3ITGAVITGA2BNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |