Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057465 | 0.84 | TP53 (1.00) | TP53MAPTHTT | |
| SCHEMBL3971657 | 0.81 | UNG (0.60) | TP53 | |
| SCHEMBL7533591 | 0.81 | TP53 (0.75) | TP53MAPTHTT | |
| SCHEMBL5298937 | 0.78 | TP53 (0.71) | TP53MAPTHTT | |
| SCHEMBL30320683 | 0.74 | TP53 (0.69) | TP53MAPTHTT | |
| SCHEMBL5311067 | 0.74 | TP53 (0.69) | TP53MAPTHTT | |
| SCHEMBL5309531 | 0.73 | TP53 (0.63) | TP53MAPTHTT | |
| SCHEMBL11997016 | 0.72 | KMT2A (0.50) | — | |
| SCHEMBL3471080 | 0.71 | — | — | |
| SCHEMBL5940601 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401829-B1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-1401829-A4 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX INC (US) | 2004-10-27 | — | — | EP | disclosed |
| US-6777420-B2 | A URACIL COMPOUNDS AS ENZYME INHIBITORS, INHIBIT BACTERIAL DNA POLYMERASE, TREATING BACTERIAL DISEASES | MICROBIOTIX, INC. | 2004-08-17 | — | — | US | disclosed |
| EP-1401829-A1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | Microbiotix, Inc. (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002102792-A1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX, INC. (US) | 2002-12-27 | — | — | WO | disclosed |
| US-6448256-B1 | PRECURSORS OF N-SUBSTITUTED DERIVATIVES OF 6-AMINOURACILS, 6-AMINOISOCYTOSINES, GUANINES AND 2-AMINOADENINES HAVING A CLEAVABLE ESTER GROUP; GREATER WATER SOLUBILITY AND ORAL BIOAVAILABILITY; TREATING GRAM POSITIVE BACTERIAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS | 2002-09-10 | — | — | US | disclosed |
| EP-1185517-A1 | ANTIBIOTIC PRODRUGS | University of Massachusetts (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071523-A1 | ANTIBIOTIC PRODRUGS | UNIVERSITY OF MASSACHUSETTS (US) | 2000-11-30 | — | — | WO | disclosed |