Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786416 | 0.99 | PARP1 (0.54) | PARP1GSK3AGSK3BHPGDTSHR | |
| Hydrochloric Acid SCHEMBL6786545 | 0.98 | PARP1 (0.53) | PARP1GSK3AGSK3BHPGDTSHR | |
| SCHEMBL6792471 | 0.97 | PARP1 (0.57) | PARP1GSK3AGSK3BHPGDTSHR | |
| SCHEMBL425918 | 0.93 | HPGD (0.54) | PARP1GSK3AGSK3BHPGDTSHR | |
| SCHEMBL30090644 | 0.93 | HPGD (0.54) | PARP1GSK3AGSK3BHPGDTSHR | |
| Water SCHEMBL27824106 | 0.92 | HPGD (0.53) | PARP1GSK3AGSK3BHPGDTSHR | |
| SCHEMBL6787974 | 0.92 | ROCK2 (0.54) | PARP1GSK3AGSK3BHPGDROCK1 | |
| SCHEMBL6786116 | 0.92 | ROCK2 (0.52) | PARP1GSK3AGSK3BHPGDROCK1 | |
| Hydrochloric Acid SCHEMBL6787362 | 0.91 | ROCK2 (0.51) | PARP1GSK3AGSK3BHPGDROCK1 | |
| SCHEMBL6788660 | 0.91 | ROCK2 (0.54) | PARP1GSK3AGSK3BHPGDROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677333-B1 | ANTIISCHEMIC AGENTS; BRAIN, CARDIOVASCULAR, MUSCULAR, AND GASTROINTESTINAL DISORDERS; ANALGESICS, ANTIDIABETIC AGENTS; RETROVIRUS SENSITIZERS; ALZHEIMER*S DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| EP-1148053-A1 | 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | claimed |
| US-6677333-B1 | ANTIISCHEMIC AGENTS; BRAIN, CARDIOVASCULAR, MUSCULAR, AND GASTROINTESTINAL DISORDERS; ANALGESICS, ANTIDIABETIC AGENTS; RETROVIRUS SENSITIZERS; ALZHEIMER*S DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-13 | — | — | US | disclosed |
| EP-1148053-A1 | 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | disclosed |