Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6788534 | 0.99 | PARP1 (0.54) | PARP1ROCK2ROCK1SMN1; SMN2HPGD | |
| SCHEMBL6782921 | 0.96 | PARP1 (0.55) | PARP1ROCK2ROCK1SMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL6788444 | 0.95 | PARP1 (0.54) | PARP1ROCK2ROCK1SMN1; SMN2HPGD | |
| SCHEMBL6792847 | 0.93 | PARP1 (0.53) | PARP1ROCK2ROCK1SMN1; SMN2HPGD | |
| SCHEMBL6782566 | 0.93 | PARP1 (0.60) | PARP1ROCK2ROCK1SMN1; SMN2HPGD | |
| SCHEMBL6793941 | 0.92 | PARP1 (0.61) | PARP1ROCK2ROCK1SMN1; SMN2HPGD | |
| SCHEMBL6788872 | 0.91 | ROCK1 (0.50) | PARP1ROCK2ROCK1HPGDNPSR1 | |
| SCHEMBL6782927 | 0.90 | PARP1 (0.48) | PARP1ROCK2ROCK1KDM4EALDH1A1 | |
| SCHEMBL6782343 | 0.90 | ROCK1 (0.49) | PARP1ROCK2ROCK1HPGDNPSR1 | |
| Hydrochloric Acid SCHEMBL6794797 | 0.90 | ROCK1 (0.49) | PARP1ROCK2ROCK1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677333-B1 | ANTIISCHEMIC AGENTS; BRAIN, CARDIOVASCULAR, MUSCULAR, AND GASTROINTESTINAL DISORDERS; ANALGESICS, ANTIDIABETIC AGENTS; RETROVIRUS SENSITIZERS; ALZHEIMER*S DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| EP-1148053-A1 | 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | claimed |