⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793809 | 0.89 | CCNB2 (0.33) | — | |
| SCHEMBL6786549 | 0.70 | CCNB2 (0.31) | — | |
| SCHEMBL6786551 | 0.70 | CCNB2 (0.31) | — | |
| SCHEMBL6788615 | 0.69 | RXRA (0.33) | — | |
| SCHEMBL6788259 | 0.69 | PDE2A (0.34) | — | |
| SCHEMBL6789137 | 0.67 | CCNB2 (0.35) | — | |
| SCHEMBL7454862 | 0.63 | SLC13A5 (0.30) | — | |
| SCHEMBL21742136 | 0.62 | SMN1; SMN2 (0.55) | — | |
| SCHEMBL6787926 | 0.61 | KDM4E (0.32) | — | |
| SCHEMBL24140202 | 0.59 | MEN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699876-B2 | FOR CANCER THERAPY | LES LABORATOIRES SERVIER (FR) | 2004-03-02 | — | — | US | disclosed |
| US-20030105109-A1 | For cancer therapy | LES LABORATOIRES SERVIER (FR) | 2003-06-05 | — | — | US | disclosed |
| US-6509345-B2 | For therapy of cancerous diseases | LES LABORATOIRES SERVIER (FR) | 2003-01-21 | — | — | US | disclosed |
| EP-1101765-B1 | Camptothecin analogues, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-08-14 | — | — | EP | disclosed |
| US-20020077325-A1 | New camptothecin analogue compounds | LAVIELLE GILBERT (FR) | 2002-06-20 | — | — | US | disclosed |
| EP-1101765-A2 | Camptothecin analogues, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-05-23 | — | — | EP | disclosed |