SCHEMBL678585

SCHEMBL678585

C=Cc1ccc(Cl)cc1.C=Cc1ccc(Cl)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.69
HSD17B10 Q99714 1/20 0.52
LMNA P02545 1/20 0.50
CYP2A6 P11509 1/20 0.50
TSHR P16473 1/20 0.50
AHR P35869 1/20 0.46
MAOB P27338 1/20 0.46
TDP1 Q9NUW8 1/20 0.42
CYP1A2 P05177 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
FBP1 P09467 2/20 0.39
IDO1 P14902 1/20 0.38
GRIN2D O15399 2/20 0.38
GRIN3B O60391 2/20 0.38
GRIN1 Q05586 2/20 0.38
GRIN2A Q12879 2/20 0.38
GRIN2B Q13224 2/20 0.38
GRIN2C Q14957 2/20 0.38
GRIN3A Q8TCU5 2/20 0.38
TRPA1 O75762 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14902 1.00
SCHEMBL3763847 0.97 ALDH1A1 (0.65) ALDH1A1HSD17B10LMNACYP2A6TSHR
Hydrogen Sulfide SCHEMBL10800730 0.97 ALDH1A1 (0.65) ALDH1A1HSD17B10LMNACYP2A6TSHR
Hydrogen Sulfide SCHEMBL29004372 0.97 ALDH1A1 (0.65) ALDH1A1HSD17B10LMNACYP2A6TSHR
SCHEMBL10545661 0.97 ALDH1A1 (0.65) ALDH1A1HSD17B10LMNACYP2A6TSHR
Vinyl Chloride SCHEMBL17390782 0.94 ALDH1A1 (0.61) ALDH1A1HSD17B10LMNACYP2A6TSHR
Methylamine SCHEMBL7516867 0.92 ALDH1A1 (0.58) ALDH1A1HSD17B10LMNACYP2A6TSHR
SCHEMBL4214945 0.92 ALDH1A1 (0.58) ALDH1A1HSD17B10LMNACYP2A6TSHR
SCHEMBL7515599 0.92 ALDH1A1 (0.58) ALDH1A1HSD17B10LMNACYP2A6TSHR
Styrene SCHEMBL137665 0.89 ALDH1A1 (0.70) ALDH1A1HSD17B10LMNACYP2A6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112359027-B Cytochrome P450 enzyme mutant and application thereof 凯莱英生命科学技术(天津)有限公司 2021-04-13 CN disclosed
CN-112359027-A Cytochrome P450 enzyme mutant and application thereof 凯莱英生命科学技术(天津)有限公司 2021-02-12 CN disclosed
US-20110275774-A1 ORGANOANTIMONY COMPOUND, PROCESS FOR PREPARING SAME, LIVING RADICAL POLYMERIZATION INITIATOR, PROCESS FOR PRODUCING POLYMER WITH USE OF SAME, AND THE POLYMER YAMAGO SHIGERU 2011-11-10 US disclosed
US-20060199927-A1 Process for production of living-radical polymers and polymers Outdoor Wireless Networks LLC 2006-09-07 US disclosed