Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.72 |
| ▸ | TNF | P01375 | 4/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.62 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6779191 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL6348648 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL6778535 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL8072134 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL8062483 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL9294255 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL8077706 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL8076183 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL6774095 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL757112 | 1.00 | ADORA2B (0.72) | ADORA2BTNFUSP2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693105-B1 | USING XANTHINYL DERIVATIVES TO REDUCE TREATMENT INDUCED TOXICITY; INHIBITING CELLULAR SIGNALING THROUGH SECOND MESSENGER PATHWAY; REDUCING CELLULAR LEVEL OF NONARACHI-DONATE PHOSPHATIDIC ACID AND DIACYLGLYCEROL | CELL THERAPEUTICS, INC. | 2004-02-17 | — | — | US | disclosed |
| US-20030054977-A1 | Manufacture of polyglutamate-therapeutic agent conjugates | CELL THERAPEUTICS, INC. | 2003-03-20 | — | — | US | disclosed |
| EP-0719267-B1 | SECOND MESSENGER CELL SIGNALING INHIBITORS | CELL THERAPEUTICS INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6133274-A | TREATING DISEASE MEDIATED BY INTRACELLULAR SIGNALING THROUGH ONE OR TWO SPECIFIC INTRACELLULAR SIGNALING PATHWAYS; A XANTHINYL HAVING AT LEAST ONE NITROGEN SUBSTITUTED BY AN HYDROXYALKYL; ANTITUMOR,-CARCINOGENIC,-ARTHRITIC AGENTS | CELL THERAPEUTICS, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-6121270-A | N-(EPOXYALKYL)XANTHINE DERIVATIVES WHICH MODULATE CELLULAR RESPONSES TO NOXIOUS, PRO-INFLAMMATORY STIMULI | CELL THERAPEUTICS, INC. (US) | 2000-09-19 | — | — | US | disclosed |
| US-6100271-A | Therapeutic compounds containing xanthinyl | CELL THERAPEUTICS, INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-6043250-A | Methods for using therapeutic compounds containing xanthinyl | CELL THERAPEUTICS, INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5866576-A | COMPOUNDS THAT ACT AS DRUGS ON THE CELLULAR AND BIOCHEMICAL LEVEL TO MODULATE CELLULAR RESPONSES TO NOXIOUS, PRO-INFLAMMATORY STIMULI. | CELL THERAPEUTICS, INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5837703-A | AUTOIMMUNE DISEASES, ARTHRITIS, CANCER, LEUKEMIA, MULTIPLE SCLEROSIS; ANTITUMOR AGENTS | CELL THERAPEUTICS, INC. (US) | 1998-11-17 | — | — | US | disclosed |
| US-5824677-A | SUBSTITUTED WITH HETEROCYCLIC RING, ANTIINFLAMMATORY, IMMUNOSUPPRESSIVE | CELL THERAPEUTICS, INC. (US) | 1998-10-20 | — | — | US | disclosed |
| US-5470878-A | Cell signaling inhibitors | CELL THERAPEUTICS, INC. (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0669825-A1 | HYDROXYL-CONTAINING COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1995022546-A1 | INTRACELLULAR SIGNALLING MEDIATORS | CELL THERAPEUTICS, INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| WO-1995020589-A1 | CELL SIGNALING INHIBITORS | CELL THERAPEUTICS, INC. (US) | 1995-08-03 | — | — | WO | disclosed |
| EP-0662834-A1 | NOVEL EPOXIDE-CONTAINING COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994022863-A9 | SECOND MESSENGER CELL SIGNALING INHIBITORS | — | 1994-12-22 | — | — | WO | disclosed |
| WO-1994022863-A1 | SECOND MESSENGER CELL SIGNALING INHIBITORS | CELL THERAPEUTICS, INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994016704-A1 | OXIME-SUBSTITUTED THERAPEUTIC COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1994-08-04 | — | — | WO | disclosed |
| WO-1994011001-A1 | HYDROXYL-CONTAINING COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1994-05-26 | — | — | WO | disclosed |
| WO-1994006431-A1 | NOVEL EPOXIDE-CONTAINING COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1994-03-31 | — | — | WO | disclosed |