Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 19/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 17/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 11/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 11/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 11/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785290 | 0.96 | ADRA1A (0.70) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6198006 | 0.93 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6200436 | 0.89 | ADRA1A (0.65) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6782399 | 0.89 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6793226 | 0.87 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785634 | 0.85 | ADRA1A (0.59) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6793160 | 0.84 | ADRA1A (0.52) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL8592793 | 0.82 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785443 | 0.82 | ADRA1A (0.65) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785064 | 0.81 | ADRA1A (0.54) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727257-B1 | HYPOTENSIVE AGENTS FOR INTRAOCULAR PRESSURE; ANTICHOLESTEROL AGENTS; RELAXING URINARY TRACT TISSUE; BENIGN PROSTATIC HYPERPLASIA, IMPOTENCY, AND CARDIOVASCULAR DISORDERS; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |