Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521016 | 0.93 | CYP2C9 (0.63) | CYP2C9CYP2C19HSD17B10MMP2MMP8 | |
| SCHEMBL28703755 | 0.86 | CYP2C9 (0.59) | CYP2C9CYP2C19HSD17B10MAPK1MMP2 | |
| SCHEMBL11563095 | 0.86 | CYP2C9 (0.55) | CYP2C9CYP2C19HSD17B10MAPK1PPARA | |
| SCHEMBL11562132 | 0.86 | CYP2C9 (0.59) | CYP2C9CYP2C19HSD17B10MAPK1MMP2 | |
| SCHEMBL933757 | 0.85 | CYP2C9 (0.54) | CYP2C9CYP2C19HSD17B10MMP2MMP8 | |
| SCHEMBL933879 | 0.85 | CYP2C9 (0.54) | CYP2C9CYP2C19HSD17B10MMP2MMP8 | |
| SCHEMBL6658202 | 0.83 | MEN1 (0.40) | CYP2C9CYP2C19HSD17B10SRCLMNA | |
| SCHEMBL6782198 | 0.83 | MEN1 (0.45) | CYP2C9CYP2C19HSD17B10SRCLMNA | |
| SCHEMBL11761904 | 0.81 | TRPA1 (0.51) | CYP2C9CYP2C19HSD17B10TRPA1LMNA | |
| SCHEMBL7321447 | 0.81 | MEN1 (0.43) | CYP2C9CYP2C19HSD17B10MAPK1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |