Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789734 | 0.83 | CYP1A2 (0.53) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL7253268 | 0.80 | CYP1A2 (0.63) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL3970289 | 0.80 | SMN1; SMN2 (0.47) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL1366357 | 0.79 | CYP1A2 (0.62) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL8232676 | 0.79 | CYP1A2 (0.62) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL6789730 | 0.78 | CYP1A2 (0.56) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL6494921 | 0.78 | CYP1A2 (0.60) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL265139 | 0.78 | NCF1 (0.61) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL994597 | 0.78 | CYP1A2 (0.60) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A | |
| SCHEMBL3921968 | 0.78 | CYP1A2 (0.60) | CYP1A2SMN1; SMN2KDM4EHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825215-B2 | N-HYDROXY-2-(2-(((4-((2-METHYL-4-QUINOLINYL)METHOXY)PHENYL) -SULFONYL)METHYL)-2-PYRROLIDINYL)ACETAMIDE, FOR EXAMPLE AND OTHER QUINOLINE CONTAINING N-HYDROXYACETAMIDE DERIVATIVES | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-30 | — | — | US | disclosed |