Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6782858 | 0.99 | PARP1 (0.48) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| SCHEMBL6782620 | 0.92 | PARP1 (0.48) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL6790105 | 0.91 | PARP1 (0.47) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| SCHEMBL6792847 | 0.89 | PARP1 (0.53) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| SCHEMBL6782921 | 0.89 | PARP1 (0.55) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| SCHEMBL6783287 | 0.89 | PARP1 (0.55) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| SCHEMBL6793749 | 0.89 | PARP1 (0.50) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL6788534 | 0.88 | PARP1 (0.54) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL6788752 | 0.88 | PARP1 (0.49) | PARP1ROCK1ROCK2HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL6788444 | 0.88 | PARP1 (0.54) | PARP1ROCK1ROCK2HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677333-B1 | ANTIISCHEMIC AGENTS; BRAIN, CARDIOVASCULAR, MUSCULAR, AND GASTROINTESTINAL DISORDERS; ANALGESICS, ANTIDIABETIC AGENTS; RETROVIRUS SENSITIZERS; ALZHEIMER*S DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| EP-1148053-A1 | 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | claimed |