Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6789144 | 1.00 | PARP1 (0.39) | PARP1L3MBTL1TTKCCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6795303 | 0.92 | KCNH2 (0.37) | PARP1L3MBTL1TTKCCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6795299 | 0.92 | KCNH2 (0.37) | PARP1L3MBTL1TTKCCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6793975 | 0.89 | KEAP1 (0.30) | — | |
| Trifluoroacetic Acid SCHEMBL6793981 | 0.89 | KEAP1 (0.30) | — | |
| Trifluoroacetic Acid SCHEMBL4256992 | 0.88 | MAPKAPK2 (0.36) | CCNA2CDK2CCNA1CDK5AURKA | |
| Trifluoroacetic Acid SCHEMBL4256994 | 0.88 | MAPKAPK2 (0.36) | CCNA2CDK2CCNA1CDK5AURKA | |
| Trifluoroacetic Acid SCHEMBL6792239 | 0.87 | MAPKAPK2 (0.31) | CDK2CDK5AURKACDK1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL6792244 | 0.87 | MAPKAPK2 (0.31) | CDK2CDK5AURKACDK1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL6794988 | 0.87 | MAPKAPK2 (0.33) | L3MBTL1KCNH2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PARP1 2423/4885L3MBTL1 4870/4885TTK 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.