Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 1.00 |
| ▸ | RET | P07949 | 2/20 | 0.78 |
| ▸ | MARK3 | P27448 | 2/20 | 0.78 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.78 |
| ▸ | MELK | Q14680 | 2/20 | 0.78 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.78 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.78 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.78 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.78 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.78 |
| ▸ | FLT3 | P36888 | 1/20 | 0.78 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.78 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.78 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.71 |
| ▸ | CDK2 | P24941 | 1/20 | 0.71 |
| ▸ | FLT4 | P35916 | 1/20 | 0.71 |
| ▸ | KDR | P35968 | 1/20 | 0.71 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.71 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789069 | 1.00 | CHEK1 (1.00) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL6790756 | 0.96 | CHEK1 (0.93) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL6217783 | 0.93 | CHEK1 (0.87) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL6212107 | 0.92 | CHEK1 (0.85) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL4807030 | 0.86 | CHEK1 (0.78) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL4806204 | 0.86 | CHEK1 (1.00) | CHEK1MARK3RPS6KA3AURKBRPS6KB1 | |
| SCHEMBL4816129 | 0.86 | CHEK1 (1.00) | CHEK1MARK3RPS6KA3AURKBRPS6KB1 | |
| SCHEMBL6215025 | 0.86 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4815954 | 0.86 | CHEK1 (1.00) | CHEK1MARK3RPS6KA3AURKBRPS6KB1 | |
| SCHEMBL6789766 | 0.85 | CHEK1 (0.73) | CHEK1RETMARK3RPS6KA3MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | CHEK1 73/4885RET 417/4885MARK3 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.