⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1975952 | 1.00 | ADH1B (0.32) | — | |
| SCHEMBL1980100 | 1.00 | ADH1B (0.32) | — | |
| SCHEMBL1975949 | 1.00 | ADH1B (0.32) | — | |
| SCHEMBL23643948 | 0.96 | ADH1B (0.31) | — | |
| SCHEMBL17709881 | 0.96 | — | — | |
| SCHEMBL28947813 | 0.96 | — | — | |
| SCHEMBL7846 | 0.92 | — | — | |
| SCHEMBL1600801 | 0.89 | — | — | |
| SCHEMBL20491430 | 0.89 | CHRM5 (0.39) | — | |
| SCHEMBL2961995 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3082 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119899122-A | Cyclobutylmethyl and phenyl substituted curcumin derivative and preparation method and application thereof | 常州大学 | 2025-04-29 | — | — | CN | claimed |
| CN-117776923-A | Crocetin diester compound and application thereof in liver cancer cell resistance | 常州大学 | 2024-03-29 | — | — | CN | claimed |
| CN-116640106-B | Phenylpiperazine compound and preparation method and application thereof | 郑州大学 | 2024-03-08 | — | — | CN | claimed |
| CN-116640106-A | Phenylpiperazine compound and preparation method and application thereof | 郑州大学 | 2023-08-25 | — | — | CN | claimed |
| CN-109071414-B | Improved process for the preparation of butorphanol tartrate | 海蔻有限公司 | 2021-11-05 | — | — | CN | claimed |
| EP-3436425-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LTD (IN) | 2021-01-06 | — | — | EP | claimed |
| US-10544101-B2 | Process for the preparation of butorphanol tartrate | HIKAL LIMITED (IN) | 2020-01-28 | — | — | US | claimed |
| US-20190127389-A1 | Processes And Oxazolidine-Containing Intermediates For The Preparation Of Morphine Analogs And Derivatives | NORAMCO, INC. (US) | 2019-05-02 | — | — | US | claimed |
| US-20190112273-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LIMITED (IN) | 2019-04-18 | — | — | US | claimed |
| EP-3436425-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | Hikal Limited (IN) | 2019-02-06 | — | — | EP | claimed |
| EP-2238100-B1 | PROCESS FOR THE SYNTHESIS OF 3-AMINO-3-CYCLOBUTYLMETHYL-2-HYDROXYPROPIONAMIDE OR SALTS THEREOF | MERCK SHARP & DOHME (US) | 2014-03-26 | — | — | EP | claimed |
| CN-103435439-A | Preparation method of bromomethyl cyclobutane | HONGSHENG SCI TECH DEV CO LTD | 2013-12-11 | — | — | CN | claimed |
| US-8586765-B2 | Process for the synthesis of 3-amino-3-cyclobuthylmethyl-2-hydroxypropionamide or salts thereof | MERCK SHARP & DOHME CORP. (US) | 2013-11-19 | — | — | US | claimed |
| US-20110034705-A1 | Process For the Synthesis of 3- Amino-3-Cyclobuthylmethyl-2-Hydroxypropionamide or Salts Thereof | SCHERING-PLOUGH CORPORATION (US) | 2011-02-10 | — | — | US | claimed |
| EP-2238100-A1 | PROCESS FOR THE SYNTHESIS OF 3-AMINO-3-CYCLOBUTYLMETHYL-2-HYDROXYPROPIONAMIDE OR SALTS THEREOF | Schering Corporation (US) | 2010-10-13 | — | — | EP | claimed |
| WO-2009085858-A1 | PROCESS FOR THE SYNTHESIS OF 3-AMINO-3-CYCLOBUTYLMETHYL-2-HYDROXYPROPIONAMIDE OR SALTS THEREOF | SCHERING CORPORATION (US) | 2009-07-09 | — | — | WO | claimed |
| EP-1633698-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF | SCHERING CORPORATION (US) | 2006-03-15 | — | — | EP | claimed |
| US-6992220-B2 | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof | SCHERING CORPORATION (US) | 2006-01-31 | — | — | US | claimed |
| US-20050020689-A1 | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof | SCHERING CORPORATION | 2005-01-27 | — | — | US | claimed |
| WO-2004113272-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF | SCHERING CORPORATION (US) | 2004-12-29 | — | — | WO | claimed |