Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678677 | 0.84 | ALK (0.58) | MEN1KMT2ACHEK1MAPTALK | |
| SCHEMBL11927556 | 0.82 | MEN1 (0.54) | MEN1KMT2ACYP2D6CYP19A1CYP2C9 | |
| SCHEMBL2920907 | 0.80 | RARB (0.52) | MEN1KMT2ACYP2D6CYP19A1CYP2C9 | |
| SCHEMBL12093381 | 0.80 | ADORA2A (0.51) | MEN1KMT2ACHEK1MAPTALK | |
| SCHEMBL679102 | 0.77 | RIPK1 (0.52) | MEN1KMT2ACHEK1MAPTALK | |
| SCHEMBL31451631 | 0.76 | MEN1 (0.61) | MEN1KMT2ACHEK1MAPT | |
| SCHEMBL21442845 | 0.73 | RARB (0.50) | MEN1KMT2ACYP2D6CYP19A1CYP2C9 | |
| SCHEMBL19910968 | 0.73 | CYP2D6 (0.54) | CYP2D6CYP19A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL3432969 | 0.73 | LSS (0.42) | CTSVCTSL | |
| SCHEMBL3733141 | 0.73 | LSS (0.42) | CTSVCTSLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | ALK, BCR, NPM1 | MEN1 1324/4885KMT2A 492/4885CYP2D6 4105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.