Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703921 | 0.87 | PTGER4 (0.49) | P2RX7PTGER4PTGER2PTGER3 | |
| SCHEMBL4994863 | 0.87 | PTGER4 (0.49) | PTGER4PTGER2PTGER3 | |
| SCHEMBL6973864 | 0.87 | PTGER4 (0.49) | P2RX7PTGER4PTGER2PTGER3 | |
| SCHEMBL6684187 | 0.76 | PTGER4 (0.58) | PTGER4PTGER2PTGER3 | |
| SCHEMBL11565978 | 0.76 | PTGER4 (0.58) | PTGER4PTGER2PTGER3 | |
| SCHEMBL6683027 | 0.75 | PTGER3 (0.59) | PTGER4PTGER2PTGER3 | |
| SCHEMBL6790317 | 0.75 | PTGER3 (0.59) | PTGER4PTGER2PTGER3 | |
| SCHEMBL6687795 | 0.74 | PTGER4 (0.49) | PTGER4PTGER2PTGER3 | |
| SCHEMBL6693834 | 0.74 | PTGER4 (0.49) | PTGER4PTGER2PTGER3 | |
| SCHEMBL6791029 | 0.74 | PTGER4 (0.66) | PTGER4PTGER2PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737437-B2 | FOR EXAMPLE, 7-(2S-(3R-HYDROXY-4-PHENYLBUTYL)-5-OXOPYRROLIDIN -1-YL)HEPTANOIC ACID; PROMOTING BONE READSORPTION; BONE LOSS, FRACTURES, AND DEFECTS; FRAILTY; CHILDHOOD IDIOPATHIC BONE LOSS; ALVEOLAR BONE LOSS, OSTEOTOMY; GUM DISEASE; PROSTHETICS | PFIZER INC. | 2004-05-18 | — | — | US | disclosed |
| US-6642266-B2 | Therapy of condition which presents with low bone mass in a mammal comprising administering to mammal an EP4 (prostaglandins) receptor selective agonist or prodrug | PFIZER INC. | 2003-11-04 | — | — | US | disclosed |
| EP-1110949-B1 | EP4 receptor selective agonists in the treatment of osteoporosis | PFIZER PROD INC (US) | 2003-09-24 | — | — | EP | disclosed |
| US-20020040149-A1 | EP4 receptor selective agonists in the treatment of osteoporosis | CAMERON KIMBERLY O'KEEFE (US) | 2002-04-04 | — | — | US | disclosed |
| US-20010047105-A1 | EP4 receptor selective agonists in the treatment of osteoporosis | PFIZER PRODUCTS INC. | 2001-11-29 | — | — | US | disclosed |
| EP-1110949-A1 | EP4 receptor selective agonists in the treatment of osteoporosis | Pfizer Products Inc. (US) | 2001-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040149-A1 | EP4 receptor selective agonists in the treatment of osteoporosis | PTGER4, PTGER1, PTGER2 | P2RX7 165/4885PTGER4 1/4885PTGER2 3/4885 |
| US-20010047105-A1 | EP4 receptor selective agonists in the treatment of osteoporosis | PTGER4, PTGER1, PTGER2 | P2RX7 165/4885PTGER4 1/4885PTGER2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.