Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800043 | 0.89 | CYP11B1 (0.36) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E | |
| SCHEMBL6794857 | 0.84 | CYP11B1 (0.38) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E | |
| Hydrochloric Acid SCHEMBL6796165 | 0.83 | CCNA2 (0.35) | MAPTCDK4CCNA2CDK2CCND3 | |
| SCHEMBL6794135 | 0.83 | CDK4 (0.38) | CYP11B1CYP11B2ADORA3ADORA2AMAPT | |
| SCHEMBL6801024 | 0.82 | CDK4 (0.37) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E | |
| SCHEMBL6801021 | 0.82 | CDK4 (0.37) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E | |
| SCHEMBL6786821 | 0.81 | SUV39H2 (0.39) | MAPTBRD4STING1 | |
| SCHEMBL4164593 | 0.80 | CCNA2 (0.38) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E | |
| SCHEMBL6788148 | 0.80 | ALDH1A1 (0.36) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E | |
| SCHEMBL6788150 | 0.80 | ALDH1A1 (0.36) | CYP11B1CYP11B2ADORA3ADORA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CYP11B1 785/4885CYP11B2 524/4885ADORA3 2377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.