Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25756855 | 0.95 | ALDH1A1 (0.53) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL25756934 | 0.95 | ALDH1A1 (0.53) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL2791323 | 0.92 | ALDH1A1 (0.51) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL498047 | 0.85 | ALDH1A1 (0.42) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL25756941 | 0.84 | ALDH1A1 (0.42) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL25756864 | 0.81 | ALDH1A1 (0.42) | ALDH1A1POLBMAPTHTTLMNA | |
| SCHEMBL6785061 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MAPTHTTMAPK1MEN1 | |
| SCHEMBL1407841 | 0.78 | ALDH1A1 (0.43) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL6791424 | 0.77 | ALDH1A1 (0.46) | ALDH1A1POLBPDE7AMAPTHTT | |
| SCHEMBL6791413 | 0.77 | HTT (0.51) | ALDH1A1MAPTHTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784184-B2 | FOR THERAPY OF RAS- ONCOGENE-DEPENDENT TUMORS, SUCH AS CANCERS OF PANCREAS, COLON, BLADDER, AND THYROID; USEFUL FOR CONTROLLING METASTASIS, SUPPRESSING ANGIOGENESIS, INDUCING APOPTOSIS, AND RAS-ASSOCIATED PROLIFERATIVE DISEASES | WYETH HOLDINGS CORPORATION | 2004-08-31 | — | — | US | disclosed |
| US-6605628-B1 | Treatment of ras oncogene-dependent tumors; controlling metastasis, suppressing angiogenesis, inducing apoptosis | WYETH HOLDINGS CORPORATION | 2003-08-12 | — | — | US | disclosed |