Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792878 | 1.00 | APP (0.53) | APPATMHCAR2POLBMAPT | |
| SCHEMBL8375820 | 0.86 | POLB (0.56) | POLBMAPTRAB9ACYP1A1CYP1B1 | |
| SCHEMBL8375818 | 0.86 | POLB (0.56) | POLBMAPTRAB9ACYP1A1CYP1B1 | |
| SCHEMBL12610085 | 0.83 | ATM (0.53) | APPATMHCAR2RAB9AKDM4E | |
| SCHEMBL13744048 | 0.82 | APP (0.42) | APPATMMAPTAKR1B10AKR1B1 | |
| SCHEMBL6058964 | 0.80 | APP (0.66) | APPATMPOLBAKR1B10AKR1B1 | |
| SCHEMBL6058957 | 0.80 | APP (0.66) | APPATMPOLBAKR1B10AKR1B1 | |
| SCHEMBL585757 | 0.80 | ALOX5 (0.50) | APPATMHCAR2AKR1B10AKR1B1 | |
| SCHEMBL585756 | 0.80 | ALOX5 (0.50) | APPATMHCAR2AKR1B10AKR1B1 | |
| SCHEMBL584558 | 0.79 | APP (0.48) | APPATMHCAR2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784295-B2 | CARRIED OUT IN THE PRESENCE OF AN INORGANIC BASE OR ORGANIC NITROGEN BASE AND A PALLADIUM COMPLEX CATALYST CONTAINING SECONDARY MONOPHOSPHINES WITH ALIPHATIC, BRANCHED OR CYCLIC SUBSTITUENTS AS LIGANDS | SOLVIAS AG (CH) | 2004-08-31 | — | — | US | disclosed |
| EP-1132361-B1 | Coupling of nucleophiles, vinyl compounds or CO with water, alcohols or amines to organic compounds | SOLVIAS AG (CH) | 2003-05-14 | — | — | EP | disclosed |
| EP-1132361-A1 | Coupling of nucleophiles, vinyl compounds or CO with water, alcohols or amines to organic compounds | Solvias AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-5698755-A | Process for preparing aromatic olefins using palladacycle catalysis | HOECHST AG (DE) | 1997-12-16 | — | — | US | disclosed |