Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | GPR6 | P46095 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30341003 | 0.98 | KDM4E (1.00) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL16731628 | 0.96 | KDM4E (0.89) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL8803482 | 0.85 | KDM4E (0.72) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL6796135 | 0.85 | KDM4E (0.71) | KDM4ESMN1; SMN2ALDH1A1TDP1ACHE | |
| SCHEMBL10819382 | 0.84 | KDM4E (0.70) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL2924537 | 0.84 | KDM4E (0.70) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL3962616 | 0.84 | KDM4E (0.70) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL30596583 | 0.83 | KDM4E (0.74) | KDM4ESMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL21794075 | 0.83 | KDM4E (0.74) | KDM4ESMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL14774793 | 0.82 | KDM4E (0.68) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |
| EP-1368354-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070523-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |