Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.44 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30596583 | 1.00 | KDM4E (0.74) | KDM4ESMN1; SMN2ALDH1A1HTTDPP4 | |
| SCHEMBL6796135 | 0.98 | KDM4E (0.71) | KDM4ESMN1; SMN2ALDH1A1HTTDPP4 | |
| SCHEMBL30341003 | 0.85 | KDM4E (1.00) | KDM4ESMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL6792953 | 0.83 | KDM4E (0.96) | KDM4ESMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL13006258 | 0.82 | MPO (0.58) | KDM4ESMN1; SMN2ALDH1A1POLBHRH3 | |
| SCHEMBL18712999 | 0.82 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2922854 | 0.82 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11618145 | 0.82 | KDM4E (0.65) | KDM4ESMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL3964348 | 0.82 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1POLBPDE2A | |
| SCHEMBL12139530 | 0.82 | KDM4E (0.65) | KDM4ESMN1; SMN2ALDH1A1HTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436446-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2020047312-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |