Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792714 | 0.88 | HCAR2 (0.55) | HCAR2CYP2C9S1PR1ESR1PTAFR | |
| SCHEMBL19150954 | 0.84 | MEN1 (0.52) | CYP2C9HSP90AA1CCNA2CDK2CCNA1 | |
| SCHEMBL6786891 | 0.82 | HCAR2 (0.48) | HCAR2CYP2C9S1PR1ESR1ESR2 | |
| SCHEMBL6792816 | 0.80 | CCNA2 (0.55) | HCAR2CYP2C9CCNA2CDK2CCNA1 | |
| SCHEMBL881069 | 0.78 | HCAR2 (0.45) | HCAR2CYP2C9S1PR1PTAFRESR2 | |
| SCHEMBL1376912 | 0.77 | HRH3 (0.48) | HCAR2CYP2C9ESR1MAOAMAOB | |
| SCHEMBL6793552 | 0.74 | CCNA2 (0.54) | HCAR2CYP2C9S1PR1ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL1656581 | 0.73 | HCAR2 (0.44) | HCAR2CYP2C9S1PR1ESR1AKR1B1 | |
| SCHEMBL6792867 | 0.73 | HCAR2 (0.56) | HCAR2CYP2C9PTAFRMAOBAKR1B1 | |
| SCHEMBL19128564 | 0.72 | KDM4E (0.59) | CYP2C9HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | HCAR2 1767/4885CYP2C9 1505/4885S1PR1 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.