Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.35 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789505 | 0.82 | SMN1; SMN2 (0.41) | MEN1CYP2D6KMT2A | |
| SCHEMBL6790555 | 0.77 | CCNA2 (0.40) | CCNA2CDK2CCNA1AURKAPLK1 | |
| Hydrochloric Acid SCHEMBL6792575 | 0.75 | PIK3CD (0.39) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6793350 | 0.74 | PIK3CD (0.36) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6798193 | 0.67 | ALDH1A1 (0.41) | CCNA2CDK2CCNA1MEN1KMT2A | |
| SCHEMBL6793588 | 0.66 | CCNA2 (0.53) | CCNA2CDK2CCNA1 | |
| Hydrochloric Acid SCHEMBL6797412 | 0.66 | CCNA2 (0.52) | CCNA2CDK2CCNA1 | |
| SCHEMBL6788861 | 0.65 | CCNA2 (0.37) | CCNA2CDK2CCNA1MEN1LMNA | |
| SCHEMBL12542 | 0.65 | PIK3CD (0.72) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL11972058 | 0.62 | HCAR2 (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PIK3CD 182/4885PIK3R2 505/4885PIK3CA 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.