Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.40 |
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 4/20 | 0.36 |
| ▸ | PLK1 | P53350 | 4/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267658 | 0.92 | CDK2 (0.37) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL1655237 | 0.91 | PLK1 (0.36) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL4260282 | 0.91 | PLK1 (0.35) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL4264451 | 0.89 | PLK1 (0.35) | MAPKAPK2CDK2PLK1PDPK1 | |
| Trifluoroacetic Acid SCHEMBL6793949 | 0.89 | MAPKAPK2 (0.41) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL4444669 | 0.88 | CDK2 (0.38) | MAPKAPK2CDK2CCNA2CCNA1AURKA | |
| SCHEMBL1658126 | 0.88 | PLK1 (0.34) | MAPKAPK2CDK2PLK1PDPK1FGFR2 | |
| SCHEMBL4270478 | 0.87 | CDK2 (0.36) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL6793064 | 0.85 | GABRP (0.36) | MAPKAPK2CDK2PLK1PDPK1POLB | |
| SCHEMBL6794533 | 0.85 | CDK2 (0.37) | CDK2CCNA2CCNA1PLK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | MAPKAPK2 2/4885CDK2 29/4885CCNA2 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.