Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946907 | 0.82 | MAPT (0.52) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL4478837 | 0.82 | BCL2L1 (0.55) | MCL1 | |
| SCHEMBL6794026 | 0.80 | SMN1; SMN2 (0.48) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL2952091 | 0.78 | SMN1; SMN2 (0.53) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL2388189 | 0.71 | MAPT (0.55) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1700332 | 0.70 | MAPT (0.54) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL2481803 | 0.70 | MAPT (0.54) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28525704 | 0.70 | MAPT (0.51) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28526212 | 0.70 | MAPT (0.54) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL16037529 | 0.69 | MAPT (0.59) | MAPTPKMPOLBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |