Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.35 |
| ▸ | IKBKB | O14920 | 9/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.34 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.34 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4267636 | 0.92 | AR (0.32) | HRH4HRH3IKBKBCREBBP | |
| Trifluoroacetic Acid SCHEMBL6794506 | 0.92 | HRH4 (0.36) | HRH4HRH3PLK1IKBKBFLT3 | |
| Trifluoroacetic Acid SCHEMBL6791878 | 0.90 | — | — | |
| Trifluoroacetic Acid SCHEMBL6792038 | 0.90 | IKBKB (0.35) | IKBKBSMN1; SMN2TACR1CREBBP | |
| Trifluoroacetic Acid SCHEMBL4267055 | 0.90 | IKBKB (0.35) | IKBKBTACR1 | |
| Trifluoroacetic Acid SCHEMBL4262642 | 0.88 | MAPKAPK2 (0.33) | PLK1MAPKAPK2 | |
| Trifluoroacetic Acid SCHEMBL4270570 | 0.88 | — | — | |
| Trifluoroacetic Acid SCHEMBL6788114 | 0.86 | RAB9A (0.33) | IKBKBSMN1; SMN2CREBBP | |
| Trifluoroacetic Acid SCHEMBL6794258 | 0.86 | GRIN2D (0.38) | — | |
| Trifluoroacetic Acid SCHEMBL6797574 | 0.84 | CRBN (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | HRH4 2096/4885HRH3 1936/4885PLK1 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.