Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4262256 | 0.89 | PARP10 (0.35) | PARP10PARP11MAPKAPK2PLK4DAPK3 | |
| SCHEMBL4262258 | 0.82 | MAPKAPK2 (0.34) | PARP10PARP11MAPKAPK2PLK4DAPK3 | |
| SCHEMBL6792250 | 0.82 | PARP10 (0.38) | PARP10PARP11MAPKAPK2PLK4DAPK3 | |
| SCHEMBL6799047 | 0.78 | PARP10 (0.47) | PARP10PARP11MAPKAPK2PLK4DAPK3 | |
| SCHEMBL4442281 | 0.75 | PARP10 (0.46) | PARP10PARP11MAPKAPK2PLK4DAPK3 | |
| Trifluoroacetic Acid SCHEMBL4270922 | 0.72 | MAPKAPK2 (0.36) | MAPKAPK2 | |
| Trifluoroacetic Acid SCHEMBL4267121 | 0.72 | MAPKAPK2 (0.44) | MAPKAPK2MTORAKR1C3AKR1C2SLC22A12 | |
| Trifluoroacetic Acid SCHEMBL6794975 | 0.69 | PIM1 (0.36) | MAPKAPK2PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL6787950 | 0.68 | PARP1 (0.35) | MAPKAPK2CSNK1A1CSNK1DCSNK1G2 | |
| Trifluoroacetic Acid SCHEMBL4262642 | 0.68 | MAPKAPK2 (0.33) | MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PARP10 1528/4885PARP11 1392/4885MAPKAPK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.