Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.32 |
| ▸ | CDK2 | P24941 | 7/20 | 0.32 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCND3 | P30281 | 3/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 5/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.31 |
| ▸ | AURKA | O14965 | 3/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.31 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | ULK1 | O75385 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4262642 | 0.84 | MAPKAPK2 (0.33) | MAPKAPK2CCNA2CDK2NTRK1PLK1 | |
| Trifluoroacetic Acid SCHEMBL6787950 | 0.84 | PARP1 (0.35) | MAPKAPK2CCNA2CDK2PLK1CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6794258 | 0.82 | GRIN2D (0.38) | — | |
| Trifluoroacetic Acid SCHEMBL4256994 | 0.82 | MAPKAPK2 (0.36) | PIM1PIM2MAPKAPK2CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL4256992 | 0.82 | MAPKAPK2 (0.36) | PIM1PIM2MAPKAPK2CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL4270922 | 0.81 | MAPKAPK2 (0.36) | MAPKAPK2 | |
| Trifluoroacetic Acid SCHEMBL6791463 | 0.81 | HRH4 (0.31) | — | |
| Trifluoroacetic Acid SCHEMBL6794419 | 0.80 | HRH4 (0.36) | MAPKAPK2PLK1PLK3PLK2 | |
| Trifluoroacetic Acid SCHEMBL4258570 | 0.80 | CCNA2 (0.40) | PIM1PIM2CCNA2CDK2PLK1 | |
| Trifluoroacetic Acid SCHEMBL6798826 | 0.80 | IKBKB (0.37) | PLK1AURKAPLK3PLK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PIM1 633/4885PIM2 370/4885MAPKAPK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.