Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 10/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791206 | 0.90 | MAPK14 (0.57) | KCNH2 | |
| SCHEMBL4385729 | 0.86 | JAK2 (0.78) | KCNH2JAK2PLK4MAPK8MAPK9 | |
| SCHEMBL6798108 | 0.85 | MAPK14 (0.54) | KCNH2KDRPTK2 | |
| SCHEMBL6793163 | 0.85 | MAPK14 (0.64) | EGFRMAPK10KDRPTK2 | |
| SCHEMBL7485933 | 0.80 | KCNH2 (0.62) | KCNH2JAK2EGFRPLK4MAPK8 | |
| SCHEMBL6792523 | 0.80 | MAPK14 (0.52) | — | |
| SCHEMBL4378310 | 0.77 | JAK2 (0.86) | JAK2JAK3HDAC3NCOR1JAK1 | |
| SCHEMBL6793261 | 0.76 | MAPK14 (0.48) | — | |
| SCHEMBL12274649 | 0.76 | JAK2 (0.77) | JAK2PLK4MAPK8MAPK9MAPK10 | |
| SCHEMBL6795873 | 0.75 | MAPK14 (0.49) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730683-B2 | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses | SMITHKLINE BEECHAM CORPORATION | 2004-05-04 | — | — | US | disclosed |
| US-20020198206-A1 | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses | SMITHKLINE BEECHAM CORPORATION | 2002-12-26 | — | — | US | disclosed |
| US-6335340-B1 | REACTING POLYMER BOUND 2-THIOPYRIMIDINE-4-YL IMINE WITH AN ISONITRILE; OXIDATION TO SULFONE OR SULFOXIDE TO RELEASE; AMINATION; ADMINISTERING AS CYTOKINE, INTERLEUKIN, AND TUMOR NECROSIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2002-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198206-A1 | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses | IL2, IFNG, IL2RA | KCNH2 3668/4885JAK2 20/4885EGFR 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.