Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hexane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.42 |
| ▸ | PPARG | P37231 | 7/20 | 0.42 |
| ▸ | PPARD | Q03181 | 7/20 | 0.42 |
| ▸ | PPARA | Q07869 | 7/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexane SCHEMBL8830653 | 0.92 | CA1 (0.43) | AKR1B1TSHRALDH1A1MEN1KMT2A | |
| Hexane SCHEMBL10672351 | 0.87 | AKR1B1 (0.50) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hexane SCHEMBL4001903 | 0.87 | AKR1B1 (0.55) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hexane SCHEMBL5750108 | 0.87 | SMN1; SMN2 (0.50) | TSHRALDH1A1MEN1KMT2AHSD17B10 | |
| Hexane SCHEMBL10631991 | 0.84 | AKR1B1 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hexane SCHEMBL20521853 | 0.84 | AKR1B1 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hexane SCHEMBL10385393 | 0.84 | AKR1B1 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hexane SCHEMBL28260291 | 0.84 | AKR1B1 (0.39) | AKR1B1GPR84PPARGPPARDPPARA | |
| Heptane SCHEMBL5171542 | 0.84 | GPR84 (0.57) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hexane SCHEMBL9227455 | 0.84 | AKR1B1 (0.52) | AKR1B1GPR84PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040048346-A1 | Synthesis of chiral intermediates useful in preparing pharmacologically active compounds | FERMENTA BIOTECH LTD. (IN) | 2004-03-11 | — | — | US | disclosed |