Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | IAPP | P10997 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817244 | 0.92 | ALOX15 (0.62) | ALOX15NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3616641 | 0.89 | ALOX15 (0.67) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| SCHEMBL9404857 | 0.89 | ALOX15 (0.67) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| SCHEMBL9405000 | 0.88 | ALOX15 (0.62) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| SCHEMBL6790422 | 0.88 | ALOX15 (0.74) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9404927 | 0.88 | ALOX15 (0.65) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| SCHEMBL6742852 | 0.86 | ALOX15 (0.63) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| SCHEMBL6793192 | 0.86 | ALOX15 (0.55) | ALOX15NCEH1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9404824 | 0.85 | ALOX15 (0.62) | ALOX15ADRB2ADRA2ADRD2ADRA2C | |
| SCHEMBL9404864 | 0.84 | ALOX15 (0.64) | ALOX15ADRB2ADRA2ADRD2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122870-A1 | Treatment Of Ischemia-Reperfusion Injury | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2012-05-17 | — | — | US | disclosed |
| US-20070032531-A1 | SPHINGOSINE KINASE INHIBITORS AND METHODS OF THEIR USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032531-A1 | SPHINGOSINE KINASE INHIBITORS AND METHODS OF THEIR USE | SPHK1, SPHK2, S1PR2 | ALOX15 622/4885ADRB2 2305/4885ADRA2A 2965/4885 |
| US-20120122870-A1 | Treatment Of Ischemia-Reperfusion Injury | SPHK1, SPHK2, S1PR2 | ALOX15 327/4885ADRB2 818/4885ADRA2A 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.