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SCHEMBL6794790

SCHEMBL6794790

NC1(C(=O)O)CC(NC(=O)c2cccc(Cl)c2)C2C(C(=O)O)C21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ GRM2 Q14416 19/20 1.00
▸ GRM3 Q14832 19/20 1.00
▸ GRM6 O15303 3/20 0.72
▸ GRM4 Q14833 1/20 0.72
▸ GRM8 O00222 1/20 0.54
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6906939 0.90 GRM2 (0.83) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6906931 0.90 GRM2 (0.83) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6792346 0.89 GRM2 (0.79) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6794351 0.88 GRM2 (1.00) GRM2GRM3GRM6GRM4GRM8
SCHEMBL7312412 0.87 GRM2 (1.00) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6788367 0.87 GRM2 (1.00) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6795693 0.87 GRM2 (0.78) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6794912 0.87 GRM2 (1.00) GRM2GRM3GRM6GRM4GRM8
SCHEMBL6794854 0.85 GRM2 (0.77) GRM2GRM3GRM6GRM4GRM8
SCHEMBL24606225 0.84 GRM2 (1.00) GRM2GRM3GRM6GRM4GRM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040116489-A1 Synthetic excitatory amino acids ELI LILLY AND COMPANY 2004-06-17 — — US claimed
US-20040116489-A1 Synthetic excitatory amino acids ELI LILLY AND COMPANY 2004-06-17 — — US disclosed