Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30596580 | 0.98 | GRIN2B (0.57) | GRIN2BMAPK1TDP1LMNAHTT | |
| SCHEMBL8054943 | 0.98 | GRIN2B (0.57) | GRIN2BMAPK1TDP1LMNAHTT | |
| SCHEMBL8806006 | 0.85 | MAPK1 (0.50) | GRIN2BMAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL11960915 | 0.85 | KMT2A (0.64) | GRIN2BMAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL15417767 | 0.85 | TDP1 (0.56) | GRIN2BMAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL10702086 | 0.84 | MAPK1 (0.52) | GRIN2BMAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL22542165 | 0.84 | LMNA (0.63) | GRIN2BMAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL5540745 | 0.84 | GRIN2B (0.50) | GRIN2BMAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL13983575 | 0.84 | CYP2A13 (0.65) | MAPK1TDP1ALDH1A1LMNAHTT | |
| SCHEMBL30596554 | 0.83 | POLB (0.57) | MAPK1ALDH1A1HTTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475263-B1 | 2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-28 | — | — | EP | disclosed |
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| EP-1857459-A2 | Pyrazolopyrimidine compound and a process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 2007-11-21 | — | — | EP | disclosed |
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |