Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12702553 | 0.74 | ALDH1A1 (0.38) | ALDH1A1HPGDKDM4ELMNACYP1A2 | |
| SCHEMBL343502 | 0.70 | GAA (0.59) | ALDH1A1HPGDKDM4ELMNACYP1A2 | |
| SCHEMBL10132606 | 0.70 | CYP1A2 (0.44) | ALDH1A1HPGDKDM4ELMNACYP1A2 | |
| SCHEMBL13743229 | 0.70 | CYP1A2 (0.41) | ALDH1A1KDM4ELMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL28348022 | 0.68 | GAA (0.58) | ALDH1A1HPGDKDM4ELMNACYP1A2 | |
| SCHEMBL678155 | 0.68 | CYP1A2 (0.40) | ALDH1A1KDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL1539573 | 0.68 | CYP11B1 (0.43) | ALDH1A1HPGDKDM4ELMNACYP1A2 | |
| SCHEMBL1539569 | 0.68 | CDC7 (0.60) | ALDH1A1HPGDKDM4ELMNACYP1A2 | |
| SCHEMBL676630 | 0.68 | CYP1A2 (0.44) | ALDH1A1HPGDKDM4ECYP1A2GAA | |
| SCHEMBL18039405 | 0.68 | PDE4A (0.42) | ALDH1A1HPGDKDM4EGAAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160255-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160255-A1 | INHIBITORS OF AKT ACTIVITY | AKT2, AKT1, PIK3CA | ALDH1A1 4692/4885HPGD 2763/4885KDM4E 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.