Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219353 | 0.81 | MEN1 (0.52) | KMT2AKDM4EMEN1ALDH1A1PRNP | |
| SCHEMBL6801253 | 0.81 | KMT2A (0.54) | KMT2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL6708133 | 0.79 | KMT2A (0.55) | KMT2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL6213101 | 0.79 | MEN1 (0.47) | KMT2AKDM4EMEN1ALDH1A1PRNP | |
| SCHEMBL6216473 | 0.79 | PTGS2 (0.47) | KMT2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL6793320 | 0.79 | KMT2A (0.52) | KMT2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL6216645 | 0.78 | PDE5A (0.57) | KMT2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL15140811 | 0.78 | ABCB1 (0.57) | KMT2AGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL6215666 | 0.78 | MEN1 (0.47) | KMT2AKDM4EMEN1ALDH1A1PRNP | |
| SCHEMBL5253644 | 0.77 | KMT2A (0.53) | KMT2AGAAKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780867-B2 | THEY EXHIBIT SPECIFIC INHIBITION OF CGMP PHOSPHODIESTERASE (PDE V) | MERCK PATENT GMBH (DE) | 2004-08-24 | — | — | US | disclosed |
| US-20030187260-A1 | Thienopyrimidines | MERCK PATENT GMBH (DE) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187260-A1 | Thienopyrimidines | TYMP, DPYD, IMPDH1 | KMT2A 3197/4885GAA 2071/4885KDM4E 2723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.