Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27949187 | 0.81 | HDAC3 (0.40) | HPGDGFERHSD17B10HDAC3HDAC4 | |
| SCHEMBL14827505 | 0.81 | HPGD (0.43) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL2242664 | 0.78 | CYP1A2 (0.49) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL19260231 | 0.77 | AHR (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL17675519 | 0.77 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL23078930 | 0.77 | HDAC3 (0.49) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL248152 | 0.77 | CMA1 (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL5643759 | 0.77 | PGR (0.51) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL12072390 | 0.77 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL1771822 | 0.77 | CA9 (0.49) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108678-A1 | (1,2,3,4-TETRAHYDROQUINOLIN-8-YL)-HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY | ALLERGAN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |
| US-6734193-B1 | REDUCE SERUM GLUCOSE AND SERUM TRIGLYCERIDE LEVELS IN DIABETIC MAMMALS WITHOUT THE UNDESIRABLE PROPERTIES OF REDUCING SERUM THYROXINE LEVELS AND TRANSIENTLY RAISING TRIGLYCERIDE LEVELS | ALLERGAN, INC. | 2004-05-11 | — | — | US | disclosed |