Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CPB1 | P15086 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28616119 | 1.00 | POLB (0.46) | POLBMITFMAPTHTTPREP | |
| SCHEMBL28611699 | 1.00 | POLB (0.46) | POLBMITFMAPTHTTPREP | |
| SCHEMBL820714 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL20666655 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL114481 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL28747 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL9640980 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL15399080 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL819017 | 0.89 | POLB (0.43) | POLBMITFMAPTHTTPREP | |
| SCHEMBL2999647 | 0.89 | POLB (0.49) | POLBMITFMAPTHTTPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833456-B2 | Heterocyclic sulfides such as 5-(2-(2R-Hydroxymethyl-pyrrolidine-1-carbonyl)-thieno(3,2-b)pyridin-7 -ylamino)-2-methyl-indole-1-carboxylic acid methylamide, used as angiogenesis inhibitors | AGOURON PHARMACEUTICALS, INC. | 2004-12-21 | — | — | US | disclosed |