Sugi Predict

Sugi Predict / Compounds / SCHEMBL114481

SCHEMBL114481

SCHEMBL114481

COC(=O)[C@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OCc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.43
▸ HTT P42858 2/20 0.42
▸ MITF O75030 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ PREP P48147 2/20 0.41
▸ PDK1 Q15118 1/20 0.41
▸ PDK2 Q15119 1/20 0.41
▸ PDK3 Q15120 1/20 0.41
▸ PDK4 Q16654 1/20 0.41
▸ FKBP1A P62942 2/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ CYP3A4 P08684 2/20 0.39
▸ TSHR P16473 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ AGTR2 P50052 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ GLA P06280 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15399080 1.00 POLB (0.43) POLBHTTMITFMAPTPREP
SCHEMBL20666655 1.00 POLB (0.43) POLBHTTMITFMAPTPREP
SCHEMBL9640980 1.00 POLB (0.43) POLBHTTMITFMAPTPREP
SCHEMBL819017 1.00 POLB (0.43) POLBHTTMITFMAPTPREP
SCHEMBL820714 1.00 POLB (0.43) POLBHTTMITFMAPTPREP
SCHEMBL28747 1.00 POLB (0.43) POLBHTTMITFMAPTPREP
SCHEMBL820890 0.91 POLB (0.43) POLBPREPPDK1PDK2PDK3
SCHEMBL7488827 0.91 POLB (0.43) POLBPREPPDK1PDK2PDK3
SCHEMBL819549 0.91 POLB (0.43) POLBPREPPDK1PDK2PDK3
SCHEMBL7131978 0.91 POLB (0.43) POLBPREPPDK1PDK2PDK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096855-A1 DEGRADERS AND USES THEREOF KUMQUAT BIOSCIENCES INC. (US) 2025-05-08 — — WO disclosed
US-20240300965-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-09-12 — — US disclosed
US-11999746-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-06-04 — — US disclosed
US-20200055863-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-02-20 — — US disclosed
US-10428078-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-10-01 — — US disclosed
EP-3172211-B1 TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 GLAXOSMITHKLINE IP DEV LTD (GB) 2019-07-03 — — EP disclosed
US-20190023715-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-24 — — US disclosed
US-10125141-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-11-13 — — US disclosed
EP-2867238-B1 PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF YM BIOSCIENCES AUSTRALIA PTY (AU) 2017-08-09 — — EP disclosed
EP-2867238-B1 PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF YM BIOSCIENCES AUSTRALIA PTY (AU) 2017-08-09 — — EP disclosed
US-20170204109-A1 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-07-20 — — US disclosed
EP-2925741-B1 PYRROLIDINE GPR40 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2016-10-26 — — EP disclosed
US-20160280680-A1 PYRROLIDINE GPR40 MODULATORS BRISTOL-MYERS SQUIBB COMPANY 2016-09-29 — — US disclosed
EP-2867238-A1 PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF YM BioSciences Australia Pty Ltd (AU) 2015-05-06 — — EP disclosed
US-8809359-B2 Phenyl amino pyrimidine bicyclic compounds and uses thereof YM BIOSCIENCES AUSTRALIA PTY LTD (US) 2014-08-19 — — US disclosed
WO-2014000032-A1 PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF YM BIOSCIENCES AUSTRALIA PTY LTD (AU) 2014-01-03 — — WO disclosed
US-20140005161-A1 PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF YM BIOSCIENCES AUSTRALIA PTY LTD (US) 2014-01-02 — — US disclosed
US-20120058989-A1 ANTIBACTERIAL FLUOROQUINOLONE ANALOGS ACHAOGEN, INC. (US) 2012-03-08 — — US disclosed
US-7598243-B2 inhibit atherosclerotic lesion formation and pathological progression by impairing monocyte recruitment and differentiation in the arterial wall; antiinflammatory, anticarcinogenic agent; autoimmune diseases MERCK & CO., INC. (US) 2009-10-06 — — US disclosed
US-20080081803-A1 Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity MERCK SHARP & DOHME CORP. 2008-04-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055863-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-20190023715-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-20080081803-A1 Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity CCR1, CCR5, CCR2 POLB 3171/4885HTT 4232/4885MITF 3477/4885
US-10125141-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-10428078-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-20120058989-A1 ANTIBACTERIAL FLUOROQUINOLONE ANALOGS RECQL, BLVRB, NQO2 POLB 455/4885HTT 4667/4885MITF 3443/4885
US-20240300965-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-20140005161-A1 PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF JAK3, JAK1, JAK2 POLB 1238/4885HTT 3623/4885MITF 1228/4885
US-11999746-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-20170204109-A1 Compounds PLAAT2, PLA2G12A, PLA2G1B POLB 3233/4885HTT 675/4885MITF 4290/4885
US-20160280680-A1 PYRROLIDINE GPR40 MODULATORS GPR55, GPR65, GPR27 POLB 4127/4885HTT 3323/4885MITF 805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.