Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799001 | 1.00 | CYP4F2 (0.43) | CYP4F2CYP4A11P2RX7NPSR1SMN1; SMN2 | |
| SCHEMBL6792780 | 0.84 | CYP2C19 (0.39) | SMN1; SMN2MMEMAPK1 | |
| SCHEMBL6792777 | 0.84 | CYP2C19 (0.39) | SMN1; SMN2MMEMAPK1 | |
| SCHEMBL6805353 | 0.71 | — | — | |
| SCHEMBL101043 | 0.70 | CYP4F2 (0.44) | CYP4F2CYP4A11P2RX7NPSR1TSHR | |
| SCHEMBL13181849 | 0.69 | CYP4F2 (0.50) | CYP4F2CYP4A11P2RX7NPSR1MME | |
| SCHEMBL2940467 | 0.68 | CYP4F2 (0.57) | CYP4F2CYP4A11P2RX7NPSR1MME | |
| SCHEMBL17155 | 0.68 | CYP4F2 (0.56) | CYP4F2CYP4A11P2RX7NPSR1MME | |
| SCHEMBL761603 | 0.68 | CYP4F2 (0.61) | CYP4F2CYP4A11P2RX7NPSR1MME | |
| SCHEMBL13715140 | 0.67 | CYP4F2 (0.47) | CYP4F2CYP4A11P2RX7NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713476-B2 | SUBSTITUTED LACTAM; GAMMA-SECRETASE INHIBITOR; DECREASES PRODUCTION OF BETA-AMYLOID; TREATMENT FOR ALTZHEIMER'S AND DOWN'S SYNDROME | DUPONT PHARMACEUTICALS COMPANY | 2004-03-30 | — | — | US | disclosed |