Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 7/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371845 | 0.87 | MAP3K14 (0.59) | ENPP2MAP3K14HTR1ADRD2DRD3 | |
| SCHEMBL11861133 | 0.83 | HCRTR1 (0.47) | HTR1AHTR2BSIGMAR1HTR7TMEM97 | |
| SCHEMBL25659961 | 0.82 | ENPP2 (0.49) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL10613752 | 0.82 | ENPP2 (0.47) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL10613891 | 0.82 | ENPP2 (0.47) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL10613885 | 0.82 | ENPP2 (0.47) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL10613749 | 0.82 | ENPP2 (0.47) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL10613757 | 0.82 | ENPP2 (0.47) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL24915967 | 0.81 | ENPP2 (0.46) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL24915659 | 0.81 | ENPP2 (0.46) | ENPP2HTR1AHTR2BSIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750243-B1 | COMPETITIVE INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES, ESPECIALLY THROMBIN; chemical synthesis; anticoagulants; treatment of thrombosis | AstraZeneća AB (SE) | 2004-06-15 | — | — | US | claimed |
| EP-0278603-B1 | CONDENSED PYRAZOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1992-12-02 | — | — | EP | disclosed |
| US-4853405-A | Condensed pyrazole derivatives, pharmaceutical compositions and use | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-08-01 | — | — | US | disclosed |
| US-4777168-A | ANTISECRETORY, ANTIULCER AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1988-10-11 | — | — | US | disclosed |
| EP-0278603-A1 | Condensed pyrazole derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-17 | — | — | EP | disclosed |
| US-4722925-A | ANTIULCER AGENTS, GASTROINTESTINAL DISORDERS | RORER PHARMACEUTICAL CORPORATION (US) | 1988-02-02 | — | — | US | disclosed |
| EP-0198918-A4 | BICYCLIC BENZO-OXY HETEROCYCLIC ETHERS AND THIOETHERS AS H 2?-RECEPTORS ANTAGONISTS. | RORER INTERNAT OVERSEAS INC (US) | 1987-08-10 | — | — | EP | disclosed |
| US-4668673-A | ANTISECRETORY, ANTIULCER, ANTACIDS | WILLIAM H. RORER, INC. (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0198918-A1 | BICYCLIC BENZO-OXY HETEROCYCLIC ETHERS AND THIOETHERS AS H 2?-RECEPTORS ANTAGONISTS | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4612309-A | Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers | WILLIAM H. RORER, INC. (US) | 1986-09-16 | — | — | US | disclosed |
| WO-1986002550-A1 | BICYCLIC BENZO-OXY HETEROCYCLIC ETHERS AND THIOETHERS AS H2-RECEPTORS ANTAGONISTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1986-05-09 | — | — | WO | disclosed |